NSAID Classes:

• Propionic acids
  • Fenoprofen
  • Ibuprofen
  • Ketoprofen
  • Naproxen
• Acetic acids
  • Diclofenac
  • Indomethacin
  • Ketorolac
  • Sulindac
  • Tolmentin
• Endic acids
  • Meloxicam
  • Piroxicam
• Anthranilic acids
  • Mefenamic acid

Risk for GI complications:

• Prior ulcer, GI bleed
• Age > 60
• High dose
• Concurrent steroids
• Concurrent anticoagulation
• 1 or 2 variables: moderate risk, use cytoprotective agent concurrently
• More than 2 variables: “don’t use”
• Other contraindications:
  • Strong history CV disease
  • Hypercoagulable state
  • Renal disease/failure
  • Low perfusion state