75 Non-Cancer Presentations with a Median Survival of Six Months or Less
Heart Failure
- Hospitalization for moderate to severe symptomatic heart failure (HF), NYHA (New York Heart Association) Class III or IV with three or more of the following:
- Age > 70
- Left Ventricular Ejection Fraction (LVEF) 20% or less
- Beta-type Natriuretic Peptide (BNP) > 950
- Cardiac troponin I > 0.4
- C-reactive protein > 3.5
- 4th hospitalization for CHF or repeat hospitalization within 2 months
- Dependency of 3 or more ADL (activities of daily living) or need for home care
- Weight loss of 2.3 kg or greater in 2 months or albumin< 2.5
- History of:
- Cardiogenic shock
- Ventricular or supraventricular arrhythmia
- Cardiac arrest
- Cardiopulmonary resuscitation or
- Mechanical ventilation
- Systolic blood pressure < 110
- Creatinine > 2 or BUN > 40
- Sodium < 135
- Cardiovascular disease:
- Ischemic cerebrovascular disease or
- Peripheral vascular disease
- Other comorbid illness:
- Diabetes
- Mellitus
- Dementia
- COPD
- Cirrhosis
- Cancer
Dementia
- Advanced dementia with dependency in all activities of daily living, bedbound status, urinary and bowel incontinence, decreased ability to communicate verbally, AND admission to a hospital or skilled nursing facility with one or more of the following:
- BMI < 18.5, decreased oral intake, or significant weight loss
- Presence of at least one pressure ulcer
- Evidence of at least one comorbid illness
- Male sex and age > 90
- Placement of a feeding tube due to inability to eat or history of aspiration
Geriatric Failure-to-Thrive
- Age > 75, albumin < 3.5, dependency in 2 or more activities of daily living, AND admission to a hospital or skilled nursing facility with one or more of the following:
- Dependency in all activities of daily living with malnutrition (weight loss >10% or albumin < 3)
- Evidence of heart failure
- Creatinine > 3
- Evidence of delirium during hospitalization
End-Stage Renal Disease (ESRD)
- ESRD on dialysis with age > 70 and 2 or more of the following:
- KPS < 50
- Significant comorbid condition such as
- Coronary artery disease
- Peripheral vascular disease
- Heart failure
- Cancer
- Malnutrition
- BMI < 19.5 or albumin < 2.2
- Residence in a skilled nursing facility
- Admission to an intensive care unit for an acute illness
- Hip fracture with inability to ambulate
- ESRD without dialysis with age > 70 and 1 or more of the following:
- Dialysis withheld due to decreased performance status and significant comorbidity
- Dialysis withdrawn due to advanced age, functional dependence, and comorbidity
Cirrhosis
- Decompensated hepatic cirrhosis and 1 or more of the following:
- Child-Pugh 12 or greater
- MELD 21 or greater
- Decompensated hepatic cirrhosis with hospitalization for an acute illness related to liver disease and 1 or more of the following:
- Child-Pugh 10 or greater
- MELD 18 or greater
- Child-Pugh 9 or greater AND dependency in 3 or more ADL AND malnutrition (significant weight loss and albumin < 2.5
- Hospitalization in an intensive care unit related to severe decompensation of liver disease, with hypotension requiring the use of vasopressors, creatinine > 1.5, OR evidence of jaundice
- Evidence of hepatopulmonary syndrome or rapidly progressive hepatorenal syndrome
Chronic Obstructive Pulmonary Disease (COPD)
- Hospitalization for a severe COPD exacerbation with hypoxemia (paO2 < 55), hypercapnia (pCO2 > 50), dependence on supplemental O2, and 3 or more of the following:
- Age > 70
- Evidence of cor pulmonale
- Repeat hospitalization within 2 months
- History of intubation/mechanical ventilation
- KPS < 60
- Need for home care after discharge
- Malnutrition (weight loss > 2.3 kg, albumin < 2.5, or BMI < 18)
- Creatinine > 2